徐强 副理事长

1徐强,南京大学生命科学学院,教授,博导,副院长。教育部长江学者特聘教授,国家杰出青年科学基金获得者,江苏省药理学会第二届、第三届副理事长。1995年入选教育部跨世纪优秀人才培养计划;1996年获国家中青年有突出贡献专家称号;1994年获第四届中国青年科技奖,同年获首届吴阶平-保罗杨森医药学研究奖二等奖,1996年获首届江苏青年科学家奖提名奖;1999年获国家杰出青年科学基金;2001年被聘为教育部长江学者奖励计划特聘教授,享受国务院特殊津贴。荣获2011年度教育部自然科学一等奖(第一完成人)。

长期从事免疫应答与炎症的药物调控研究,主持国家自然科学基金重大研究计划重点支持项目、国家自然科学基金重点项目、国家重大科技专项“重大新药创制”等。发表原著论文200余篇,其中SCI收载150余篇,总影响因子>500,包括Autophagy, J Immunol, Leukemia, Am J Pathol, J Allergy Clin Immunol, Clin Chem, Mol Cancer Ther, Angew Chem Int Ed, PLoS One, Mol Pharmacol, Biochem Pharmacol等杂志。

5年主要论文:

1.  WJ Guo, YM Zhang, L Zhang, B Huang, FF Tao, W Chen, ZJ Guo*, Q Xu*, Y Sun*. Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells distinct from cisplatin. Autophagy 2013; 9: 996-1008.
2. Xingxin Wu, Wenjie Guo, Limei Wu, Yanhong Gu, Liyun Gu, Suhai Xu, Xuefeng Wu, Yan Shen, Yuehai Ke, Renxiang Tan, Yang Sun and Qiang Xu*. Selective sequestration of STAT1 in the cytoplasm via phosphorylated SHP-2 ameliorates murine experimental colitis. J Immunol 2012, 189: 3497-3507.
3.  Xue-Feng Wu, Xing-Xin Wu, Wen-Jie Guo, Qiong Luo, Yan-Hong Gu, Yan Shen, Ren-Xiang Tan, Yang Sun, Qiang Xu*. Cerebroside D, a glycoceramide compound, improves experimental colitis in mice with multiple targets against activated T lymphocytes. Toxicol Applied Pharmacol 2012; 263: 296-302.

4.  Wei Fang, Shen Ji, Nan Jiang, Wei Wang, Guo Yan Zhao, Su Zhang, Hui Ming Ge, Qiang Xu, Ai Hua Zhang, Ying Lao Zhang, Yong Chun Song, Jie Zhang, Ren Xiang Tan*. Naphthol radical couplings determine structural features and enantiomeric excess of dalesconols in Daldinia eschscholzii. Nature Commun 2012; 3: 1039.

5.  Xing-Xin Wu, Yang Sun, Wen-Jie Guo, Yan-Hong Gu, Xue-Feng Wu, Ren-Xiang Tan, Qiang Xu*. Rebuilding the balance of STAT1 and STAT3 signalings by fusaruside, a cerebroside compound, for the treatment of T-cell-mediated fulminant hepatitis in mice. Biochem Pharmacol 2012; 84: 1164-1173.

6. Wenjie Guo, Wen Liu, Shaocheng Hong, Hailiang Liu, Cheng Qian, Yan Shen, Xuefeng Wu, Yang Sun, Qiang Xu*. Mitochondria-Dependent Apoptosis of Con A-Activated T Lymphocytes Induced by Asiatic Acid for Preventing Murine Fulminant Hepatitis. PLos One 2012; 7(9): e46018.

7. Wenjie Guo, Wen Liu, Gong Chen, Shaocheng Hong, Cheng Qian, Ning Xie, Xiaoling Yang, Yang Sun, Qiang Xu*. Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathways. Int Immunopharmacol 2012; 14: 613-619.

8.  Peng Teng, Hai-Liang Liu, Lei Zhang, Li-Li Feng, Yue Huai, Zhang-Shuang Deng, Yang Sun, Qiang Xu, Jian-Xin Li*. Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory agents. Eur J Med Chem 2012; 50: 63-74.

9.  Yan Shen, Qiong Luo, Huimin Xu, Fangyuan Gong, Xiaobin Zhou, Yang Sun, Xuefeng Wu, Wen Liu, Guangzhi Zeng, Ninghua Tan, Qiang Xu*. Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis. Biochem Pharmacol 2011; 82: 260-268.

10. Xingxin Wu, Limei Wu, Jingjing Fan, Yu Qin, Gong Chen, Xuefeng Wu, Yan Shen, Yang Sun,
Qiang Xu*.Cortex Dictamni extract induces apoptosis of activated hepatic stellate cells via STAT1 and attenuates liver fibrosis in mice. J Ethnopharmacol 2011; 135: 173-178.

11. Hui Ming Ge , Wei Yan , Zhi Kai Guo , Qiong Luo , Rui Feng , Le Yun Zang , Yan Shen, Rui Hua Jiao, Qiang Xu, Ren Xiang Tan*. Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action. Chem Commun (Camb). 2011; 47(8): 2321-2323.

12. Ying L. Zhang, Jie Zhang, Nan Jiang, Yan H. Lu, Lu Wang, Su H. Xu, Wei Wang, Gao F. Zhang, Qiang Xu, Hui M. Ge, Jing Ma, Yong C. Song, and Ren X. Tan*. Immunosuppressive Polyketides from Mantis-Associated Daldinia eschscholzii. J Am Chem Soc. 2011; 133: 5931-5940.

13. Ye Yin, Yang Sun, Liyun Gu, Fangyuan Gong, Xingxin Wu, Yan Shen, Qiang Xu*. Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells. Eur J Pharmacol 2011; 651: 205-211.

14. Qiong Luo, Yang Sun, Xingxin Wu, Fangyuan Gong, Liyun Gu, Yanhong Gu, Qiang Xu*. Erlotinib inhibits T-cell-mediated immune response via down-regulation of the c-Raf/ERK cascade and Akt signaling pathway. Toxicol Appl Pharmacol 2011; 251: 130-136.

15. Lu Wang, Lingxian Wang, Yanhong Gu, Yongqian Shu, Yan Shen, Qiang Xu*. Integrin a6high cell population functions as an initiator in tumorigenesis and relapse of human liposarcoma. Mol Cancer Ther 2011; 10: 2276-2286.

16. Lu Wang, Lingxian Wang, Ran Song, Yan Shen, Yang Sun, Yanhong Gu, Yongqian Shu, Qiang Xu*. Targeting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma. Mol Cancer Ther 2011; 10: 461-471.

17. Jianliang Xu, Shaoxian Cao, Lu Wang, Rui Xu, Gong Chen, Qiang Xu*. VEGF promotes the transcription of human PRL-3 gene in HUVEC through transcription factor MEF2C. PLoS ONE 2011; 6: e27165.

18. Su Feng, Wei Chen, Dan Cao, Jinjun Bian, Fang-Yuan Gong, Wei Cheng, Shun Cheng, Qiang Xu, Zi-Chun Hua, Wu Yin*. Involvement of Na+, K+-ATPase and its inhibitors in lung epithelial inflammation by HuR-mediated cytokine mRNA stabilization. Cell Mol Life Sci 2011; 68: 109-124.

19. Wei Zhao, Tao Zhang, Bingqian Qu, Xingxin Wu, Xu Zhu, Fanyu Meng, Yanhong Gu, Yongqian Shu, Yan Shen, Yang Sun, Qiang Xu*. Sorafenib induces apoptosis of HL60 cells through inhibiting Src kinase mediated STAT3 phosphorylation. Anti-Cancer Drugs 2011; 22(1): 79-88.

20. Yanhong Gu, Wei Zhao, Fanyu Meng, Bingqian Qu, Xu Zhu, Yang Sun, Yongqian Shu, Qiang Xu*. Sunitinib impairs the proliferation and function of human peripheral T cell and prevents T-cell-mediated immune response in mice. Clin Immunol 2010; 135: 55-62.

21. Fangyuan Gong, Yan Shen, Qi Zhang, Yang Sun, Jiayu Tang, Feifei Tao, Qiang Xu*. Obaculactone suppresses Th1 effector cell function through down-regulation of T-bet and prolongs skin graft survival in mice. Biochem Pharmacol 2010; 80: 218-225.

22. Yang Sun, Xingxin Wu,Ye Yin, Fangyuan Gong, Yan Shen, Tiantian Cai, Xiaobin Zhou, Xuefeng Wu, Qiang Xu*. Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-γ signaling in a murine model of inflammatory bowel disease. Biochem Pharmacol 2010; 79: 229-238.

23. Hui Ming Ge, Wen Hao Yang, Yan Shen, Nan Jiang, Zhi Kai Guo, Qiong Luo, Qiang Xu, Jing Ma, and Ren Xiang Tan*. Immunosuppressive Resveratrol Aneuploids from Hopea chinensis. Chem-Eur J 2010; 16: 6338-6345.

24. Feng Fang, Yijun Tang, Zhe Gao, Qiang Xu*. A novel regulatory mechanism of naringenin through inhibition of T lymphocyte function in contact hypersensitivity suppression. Biochem Biophy Res Comm 2010; 397: 163-169.

25. Guo-Biao Liu, Jian-Liang Xu, Mei Geng, Rui Xu, Rong-Rong Hui, Jian-Wei Zhao, Qiang Xu, Hong-Xi Xu, Jian-Xin Li*. Synthesis of a novel series of diphenolic chromone derivatives as inhibitors of NO production in LPS-activated RAW264.7 macrophages. Bioorg Med Chem 2010; 18: 2864-2871.

26. Yang Sun, Yu Qin, Fang-Yuan Gong, Xue-Feng Wu, Zi-Chun Hua, Ting Chen, Qiang Xu*. Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice. Biochem Pharmacol2009; 77 (11): 1717-1724.

27. Xiao-dan Wang, Min-xin Meng, Ling-bo Gao, Ting Liu, Qiang Xu, Su Zeng*. Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp. Int
J Pharmaceut
2009; 378: 1-8.

28. Guo-Biao Liu, Jian-Liang Xu, Cui-Cui He, Gong Chen, Qiang Xu, Hong-Xi Xu, Jian-Xin Li*. Synthesis and evaluation of a novel series of quinoline derivatives with immunosuppressive activity. Bioorg Med Chem 2009; 17: 5433-41.

29. Yang Sun, Tian-Tian Cai, Xiao-Bin Zhou, Qiang Xu*. Saikosaponin a inhibits the proliferation and activation of T cells through cell cyclearrest and induction of apoptosis. Int Immunopharmacol 2009; 9: 978-983.

30. Yanhong Gu, Yongqian Shu, Qiang Xu*.A study of weekly paclitaxel plus 5-fluorouracil and cisplatin for patients with advanced or recurrent inoperable gastric cancer. Biomed Pharmacother 2009; 63: 293-296.

31. Yan Liang, Qiang Xu, An Kang, Yuan Xie, Tong Xie, Li Liu, Haiping Hao, Lin Xie, Guangji Wang*. Validation and application of an LC-ESI-MS method for simultaneous determination of astilbin and its major metabolite 3’-O-methylastilbin in rat plasma. J Chromatography B 2009; 877: 1765-1770.

32. Ran Song, Feng Qian, Yu-Pei Li, Xia Sheng, Shao-Xian Cao, Qiang Xu*. Phosphatase of regenerating liver-3 localizes to cyto-membrane and is required for B16F1 melanoma cell metastasis in vitro and in vivo. PLoS One 2009; 4(2): e4450.

33. Yang Sun, Yi Dong, Huijuan Jiang, Tiantian Cai, Liang Chen, Xiang Zhou, Ting Chen, Qiang Xu*. Dissection of the role of paeoniflorin in the traditional Chinese medicinal formula Si-Ni-San against contact dermatitis in mice. Life Sci 2009; 84: 337-44.

34. Lu Wang, Yan Shen, Ran Song, Yang Sun, Jianliang Xu, Qiang Xu*. An Anticancer Effect of Curcumin Mediated by Down-regulating PRL-3 Expression on Highly Metastatic Melanoma Cells. Mol Pharmacol 2009; 76(6): 1238-1245.

35. Wei Zhao, Yanhong Gu, Ran Song, Bingqian Qu, Qiang Xu*. Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation.
Leukemia 2008; 22(6): 1226-33.

36. Xin Sheng, Xun Guo, Xiao-Min Lu, Guo-Yuan Lu*, Ying Shao, Fang Liu, Qiang Xu. DNA binding, cleavage, and cytotoxic activity of the preorganized dinuclear Zinc (II) complex of triazacyclononane derivatives. Bioconjug Chem 2008; 19: 490-498.

37. Hong-wei Yi, Xiao-min Lu, Feng Fang, Jun Wang, Qiang Xu*. Astilbin inhibits the adhesion of T lymphocytes via decreasing TNF-α and its associated MMP-9 activity and CD44 expression. Int Immunopharmacol 2008; 8: 1467-1474.

38. Ying Lao Zhang, Hui Ming Ge, Wei Zhao, Hao Dong, Qiang Xu, Shu Hua Li, Jing Li, Jie Zhang, Yong Chun Song, Ren Xiang Tan*. Unprecedented Immunosuppressive Polyketides from Daldinia eschscholzii, a Mantis-associated Fungus. Angew Chem Int Ed 2008; 47: 5823-5826.

39. Xia Sheng, Yang Sun, Ye Yin, Ting Chen, Qiang Xu*. Cirsilineol inhibits proliferation of cancer cells by inducing apoptosis via mitochondrial pathway.
J Pharm Pharmacol 2008; 60(11): 1523-1529.

40. Fangyuan Gong, Yan Shen, Chaofeng Zhang, Jianliang Xu, Xuefeng Wu, Zichun Hua, Qiang Xu*. Dregea volubilis ameliorates concanavalin A-induced liver injury by facilitating apoptosis of activated T cells. Exp Biol Med 2008; 233(9): 1124-1132.
41. Ye Yin, Fang-yuan Gong, Xing-xin Wu, Yang Sun, Yi-hua Li, Ting Chen, Qiang Xu*. Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. J. Ethnopharmacol. 2008; 120 (1): 1-6.

42. Limei Wu, Xingxin Wu, Yang Sun, Xiangwen Kong, Yihua Zhang, Qiang Xu*. A novel synthetic oleanolic acid derivative (CPU-II(2)) attenuates liver fibrosis in mice through regulating the function of hepatic stellate cells. J Biomed Sci 2008; 15: 251-259.

43. Jian Zhang, Yang Sun, Jihua Liu, Boyang Yu*, Qiang Xu. Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the
cytotoxic structure-activity relationship (SAR). Bioorg Med Chem Lett2007; 17(22): 6062-6065.

44. Liang Chen, Ye Yin, Hongwei Yi, Qiang Xu, Ting Chen*. Simultaneous quantification of five major bioactive flavonoids in Rhizoma Smilacis Glabrae by high-performance liquid chromatography.J Pharmaceut Biomed Anal 2007; 43: 1715-1720.

45. Xiao-Min Lu, Hong-Wei Yi, Jian-Liang Xu, Yang Sun, Jian-Xin Li, Shao-Xian Cao, Qiang Xu*. A novel synthetic oleanolic acid derivative with amino acid conjugate suppresses tumor growth through inducing cell cycle arrest. J Pharm Pharmacol 2007; 59(8): 1087-1093.

46. Yan Shen, Jia Chen, Xianming Zhang, Qiang Xu*. Human TNF-alpha gene vaccination ameliorates collagen-induced arthritis in mice. Int Immunopharmacol2007; 7: 1140-1149.

47. Jingwen Chen, Xiaoyong Wang, Ying Shao, Jianhui Zhu, Yangguang Zhu, Yizhi Li, Qiang Xu, Zijian Guo*. A trinuclear copper (II) complex of 2, 4, 6-tris(di-2-pyridylamine)-1,3,5-triazine shows prominent DNA cleavage activity.Inorg Chem 2007; 46: 3306-3312.

48. Feng Qian, Yu-pei Li, Xia Sheng, Zichao Zhang, Ran Song, Wei Dong, Shaoxian Cao, Zichun Hua, Qiang Xu*. PRL-3-siRNA Inhibits the Metastasis of B16-BL6 Mouse Melanoma Cells in vitro and in vivo. Mol Med 2007; 13(3-4): 151-159.

49. Jianming Guo, Qiang Xu*, Ting Chen. Identification of a new metabolite of astilbin in rats. Clin Chem 2007; 53: 465-471.

50. Xin Sheng, Xiao-Min Lu, Jing-Jing Zhang, Yue-Ting Chen, Guo-Yuan Lu*, Ying Shao, Fang Liu, Qiang Xu. Synthesis and DNA cleavage activity of artificial
receptor 1, 4, 7-triazacyclononane containing guanidinoethyl and hydroxyethyl side arms. J Org Chem 2007; 72(5): 1799-802.

51. Xin Sheng, Xiao-Min Lu, Yue-Ting Chen, Guo-Yuan Lu, Jing-Jing Zhang, Ying Shao, Fang Liu, Qiang Xu*. Synthesis, DNA binding, cleavage, and cytotoxic activity of new 1, 7-dioxa-4, 10-diazacyclododecane artificial receptors containing bisguanidinoethyl or diaminoethyl double side arms. Chem-Eur J 2007; 13: 9703-9712.

52. Mingjian Fei, Xuefeng Wu, Qiang Xu*. Astilbin inhibits contact hypersensitivity via negative cytokine regulation distinct from cyclosporin A. J Allergy Clin Immunol 2005; 116(6): 1350-1356.

53. Ying*Hu Zeng, Xianming Zhang,*Xiaopeng Wu, Haibo Sha, Xiaomei Ge, Minyue Zhang, Xiang Gao, Qiang Xu*. Phosphatase of*Zhao, Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells. Am J Pathol 2004; 164(6): 2039-2054.

54. 徐强,孙洋,高翔,顾艳宏,钱峰,王璐,赵蔚,张先明,沈燕,宋然,曹少先,肿瘤转移的新分子靶点及其靶向药物的研究,教育部,教育部自然科学一等奖,2011年。
其它

中国发明专利授权十余件,美国、澳大利亚、韩国专利授权各1件。